#AceHealthReport – July.29: The agreement with GSK and Sanofi Pasteur, which combined have the largest vaccine manufacturing capability in the world, will supply the UK with 60 million doses of their Covid-19 vaccine, which is based on existing DNA-based technology used to produce Sanofi’s flu vaccine: If the GSK and Sanofi vaccine candidate is proven effective in human studies, the UK could be able to vaccinate priority groups, such as frontline health and social care workers and those at increased health risk, as soon as summer 2021: Human clinical studies of the vaccine will begin in September followed by a Phase 3 study in December 2020: With today’s announcement, the UK Government has now secured early access to four different types of immunisation and a total of 250 million doses, giving the UK the most likely chance of finding a safe and effective vaccine at the quickest speed:
Government further boosts chances of country receiving #COVID19 vaccine with an agreement GSK & Sanofi Pasteur
Deal announced which will secure early access to a promising new coronavirus vaccine, enhancing the UK’s growing portfolio of vaccine candidates.
Business Secretary Alok Sharma said:
Our scientists and researchers are racing to find a safe and effective vaccine at a speed and scale never seen before. While this progress is truly remarkable, the fact remains that there are no guarantees.
In the meantime, it is important that we secure early access to a diverse range of promising vaccine candidates, like GSK and Sanofi, to increase our chances of finding one that works so we can protect the public and save lives.
UK Government Minister for Scotland Iain Stewart said:
Today’s announcement is another encouraging development for us. Our growing portfolio of vaccines is a result of the UK Government’s work to keep people across the UK safe and provide long-term protection from COVID-19.
This latest agreement comes as the UK Government confirmed that almost 72,000 people have volunteered to receive information about participating in future vaccine studies following the launch of the NHS Covid-19 vaccine research registry last week: Only large-scale clinical studies can give scientists and regulators the assurances they need that vaccines secured are safe and effective for use. That is why the Government is urging the British public to back the national effort to speed up vaccine research by signing up to www.nhs.uk/coronavirus to receive information about becoming a volunteer for clinical studies. The aim is to get 500,000 people signed up by October:
Kate Bingham, Chair of the UK Government’s Vaccines Taskforce, said:
Through this agreement with GSK and Sanofi, the Vaccine Taskforce can add another type of vaccine to the three different types of vaccine we have already secured.
This diversity of vaccine types is important because we do not yet know which, if any, of the different types of vaccine will prove to generate a safe and protective response to COVID-19. Whilst this agreement is very good news, we mustn’t be complacent or over optimistic.
The fact remains we may never get a vaccine and if we do get one, we have to be prepared that it may not be a vaccine which prevents getting the virus, but rather one that reduces symptoms.
Thomas Triomphe, Executive Vice President and Global Head of Sanofi Pasteur commented:
With our partner GSK, we are pleased to cooperate with the UK government as well as several other countries and global organizations as part of our ongoing efforts to ensure a safe and effective vaccine is available to everyone as quickly as possible. We greatly appreciate the UK government’s support of this shared vision.
Roger Connor, President of GSK Vaccines added:
We believe that this adjuvanted vaccine candidate has the potential to play a significant role in overcoming the COVID-19 pandemic, both in the UK and around the world. We thank the UK Government for confirmation of purchasing intent, which supports the significant investment we are already making as a company to scale up development and production of this vaccine.
Earlier this month, the UK Government announced it had secured 90 million Covid-19 vaccine doses thanks to partnerships with the BioNTech / Pfizer alliance and Valneva. A deal has also been agreed to secure access to treatments containing Covid-19 neutralising antibodies from AstraZeneca, to protect those who cannot receive vaccines such as cancer and immunocompromised patients: This is in addition to an existing global licensing agreement signed with AstraZeneca and the University of Oxford to research, develop and manufacture a Covid-19 vaccine for the UK public. AstraZeneca will work to produce 100 million doses for the UK in total:
The UK Government will secure supplies for the whole of the UK: When coronavirus invades the body, the immune system fights back in multiple ways including by producing antibodies to neutralize the virus. These antibodies bind to the spike protein on the surface of the coronavirus and prevent them from entering the cells: GSK and Sanofi’s vaccine includes the coronavirus spike protein and the immune boosting adjuvant to trigger a strong and long-lasting immune response (including the production of neutralising antibodies) against COVID-19 especially in the elderly who are likely to be a priority population for early COVID-19 vaccination:
The four different vaccine classes that the UK government has secured to date for the UK are adenoviral vaccines (Oxford/AZ), mRNA vaccines (BioNTech/Pfizer & Imperial), inactivated whole virus vaccines (Valneva) and protein adjuvant vaccines (Agamemnon) In addition the UK has secured rights to AstraZeneca’s antibody treatment to neutralise the virus which can be used both as a short term prophylactic for those people who cannot receive vaccines (eg cancer and immunosuppressed patients) and front line workers exposed to the virus, as well as a treatment for infected patients.
#AceHealthDesk report ………….Published: July.29: 2020:
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